2021-04-07 · Drugs used in chemotherapy, such as tretinoin and arsenic trioxide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Gemtuzumab ozogamicin is a monoclonal antibody, called gemtuzumab, linked to a chemotherapy drug called ozogamicin.

Standard chemotherapy-containing treatments necessitate the use of blood A treatment regimen consisting of all-trans retinoic acid and arsenic trioxide was 

INDICATION. Induction of remission and consolidation in adult patients with. • newly diagnosed low-to-intermediate risk acute  This is not surprising, since the combination of ATRA plus arsenic trioxide without chemotherapy has a 98% 5-year event-free survival in low- risk patients and  Dec 5, 2016 SAN DIEGO – All-trans retinoic acid (ATRA) plus arsenic trioxide with or without chemotherapy induces high remission rates among patients  Arsenic Trioxide (Trisenox) is given intravenously (IV) to treat cancer. Find side effects, allergic reactions, and food and drug interactions. Mar 1, 2021 Arsenic trioxide injection is used together with another medicine (eg, tretinoin) to treat newly-diagnosed low-risk acute promyelocytic leukemia  Dec 31, 2000 The injectable form of arsenic trioxide (Trisenox) was recently md, investigator in the Developmental Chemotherapy Service atMemorial  Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia. Blood 2006;107:3469- 3473.

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If you are a woman, do not use arsenic trioxide if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose. Background: We recently showed that the combination of ATRA and arsenic trioxide (ATO) is at least not inferior and possibly superior to standard ATRA and chemotherapy (CHT) in the front-line management of low/intermediate risk APL (Italian-German APL 0406 trial; Lo-Coco et al., NEJM 2013). Arsenic Trioxide 0.3mg/kg Day 1-5 Twice weekly NONE 0.25mg/kg Administration Details: Table 2: Administration details for tretinoin (ATRA) and arsenic trioxide Drug Route Diluent and Rate Tretinoin (ATRA) aPO n/a Arsenic trioxide IV infusion 250ml of 0.9% NaCl over 2 hoursb a Tretinoin (ATRA) is available as 10mg capsules. Arsenic trioxide was approved in 2000 for patients with refractory or relapsed APL following retinoid and anthracycline chemotherapy.

This is not surprising, since the combination of ATRA plus arsenic trioxide without chemotherapy has a 98% 5-year event-free survival in low- risk patients and 

Blood 2006;;107(9):346973.- 2021-04-07 2021-03-17 Arsenic trioxide has been investigated in 77 newly diagnosed patients with low to intermediate risk APL, in a controlled, randomized, non-inferiority Phase 3 clinical study comparing the efficacy and safety of arsenic trioxide combined with all-trans-retinoic acid (ATRA) with those of ATRA+chemotherapy (eg, idarubicin and mitoxantrone) (Study APL0406). /day for 14 days and the dose of arsenic trioxide was reduced to 0.08 mg/kg/day. In particular, the compulsory use of prednisone (or prednisolone) as prophylactic therapy and the delayed introduction of arsenic trioxide on day 9 of the induction therapy was expected to almost completely eliminate the severest form of APL differentiation syndrome. Colloidal gadolinium arsenite has been developed as an arsenic trioxide nanoparticle prodrug (ATONP) by our group in the past five years, and it has illustrated to be highly promising for cancer therapy.

Studies on treatment of APL with Arsenic Trioxide: remission induction, follow up and Arsenic Trioxide in comparison with chemotherapy and bone marrow 

chemotherapy with ATRA plus arsenic trioxide in patients with APL classified as low-to-intermediate risk (white-cell count, ≤10×109 per liter). Patients were randomly assigned to receive either ATRA plus arsenic trioxide for induction and consolidation therapy or standard ATRA–idarubicin induction therapy Arsenic trioxide (ATO) is highly effective for the treatment of patients with acute promyelocytic leukemia (APL).

1. Lo-Coco F, Avvisati G, Vignetti M, et al. Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med 1998;339(19):1341-48.
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Colloidal gadolinium arsenite has been developed as an arsenic trioxide nanoparticle prodrug (ATONP) by our group in the past five years, and it has illustrated to be highly promising for cancer therapy. Here, we systemically synthesized arsenites of all the rare-earth elements, characterized their element-d We examined whether combining all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) might be an alternative to ATRA plus chemotherapy in untreated acute promyelocytic leukemia (APL).Twenty-five low-risk patients (white blood cell [WBC] count less than 10 × 10 9 /L [10 000/μL]) received ATRA (45 mg/m 2 daily) and ATO (0.15 mg/kg daily, beginning day 10 of ATRA), and in complete remission Arsenic Trioxide may be temporarily discontinued in the presence of o Differentiation syndrome (Table 1) o Hepatotoxicity (Table 1) o QT prolongation on ECG (see Arsenic Trioxide and QT prolongation below) Arsenic Trioxide will need to be discontinued permanently in the event of cardiac arrhythmias or severe neurological toxicity. Consolidation therapy of arsenic trioxide alternated with chemotherapy achieves remarkable efficacy in newly diagnosed acute promyelocytic leukemia Cheng-cheng Liu,1-3,* Hua Wang,1-3,* Wei-da Wang,1-3 Meng-yuan Zhu,1-3 Qi-rong Geng,1-3 Yue Lu1-31Department of Hematological Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, People’s Republic of China; 2State Key Laboratory of Oncology Description: Arsenic trioxide, an antineoplastic agent, induces apoptosis by causing morphological changes and DNA fragmentation in acute promyelocytic leukemia (APL) cells.It also damages and degrades promyelocytic leukemia (PML)-retinoic acid receptor (RAR)-α fusion gene, a characteristic of APL. Pharmacokinetics: 1.

Br J Oral Maxillofac  Studies on treatment of APL with Arsenic Trioxide: remission induction, follow up and Arsenic Trioxide in comparison with chemotherapy and bone marrow  day 15 blast clearance in risk-adapted remission induction chemotherapy for younger retinoic acid, idarubicin, and IV arsenic trioxide as initial therapy in acute  Anti-cancer Drugs ✓ Product: ARSENOX ✓Manufacturer: INTAS PHARMACEUTICALS LIMITED ✓Generic: Arsenic Trioxide ✓Type: Injection Vial​ ✓Strength:  16 aug. 2019 — Arsenic trioxide and all-trans retinoic acid treatment for acute Döhner H. Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a  Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Despite good response to the initial chemotherapy, SCLC cells often develop multidrug  APL-risk och APL med mellanrisker. Det finns mindre information tillgänglig om hur ATRA + ATO kan jämföras med ATRA + chemo hos patienter med högrisk  METRONOMIC CHEMOTHERAPY WITH GMX1777 REGRESSES MYCN-​AMPLIFIED Characterization of arsenic trioxide-induced neuroblastoma cell death 31 mars 2021 — Koncentrat till infusionsvätska, 1 mg/ml, Arsenic Trioxide Accord 2569, Dutasterid, Kapsel, 0,5 mg, Dutasteride Chemo Ibérica, 0,5 mg  Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Despite good response to the initial chemotherapy, SCLC cells often develop multidrug  My current research focuses on using sulfidated and non-sulfidated zerovalent iron micro- and nanoparticles for remdiation soils contamianted with arsenic. Chemosphere 222.
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Factors Determining Sensitivity and Resistance of Tumor Cells to Arsenic Trioxide in Patients with Cancer Cachexia Receiving Chemotherapy--a Pilot Study

Arsenic trioxide is readily absorbed by the digestive system: toxic effects are also well known upon inhalation or upon skin contact. Elimination is rapid at first (half-life of 1–2 days), by methylation to monomethylarsonic acid and dimethylarsonic acid, and excretion in the urine, but a certain amount (30–40% in the case of repeated exposure) is incorporated into the bones, muscles, skin A total of 43 of 68 patients in the ATRA–arsenic trioxide group (63%) and 4 of 69 patients in the ATRA–chemotherapy group (6%) had grade 3 or 4 hepatic toxic effects during induction or With TRISENOX ® (arsenic trioxide) injection + tretinoin 1. Indication.